The hero must pass through each mythology in pursuit of Seth before reaching the game's final showdown.

[7] The players can create their playable character choosing between a male or female warrior and mage characters from the Norse, Greek, Egyptian and Aztec mythologies and take part in four different campaigns that can be played solo or with up to six players.

Regardless of the player's goal in Loki, the gameplay path will always be slaughtering horde of monsters through deserts, caves, volcanoes and jungles.

Besides following the Diablo template, Loki still manages to mostly pull it off by sticking to the featuring an extreme difficulty even on the easiest "mortal" game setting, resulting in players respawning at the beginning of levels and areas multiple times before they actually conquer their enemies in battle.

Reviews pointed out technical issues with the game's engine struggling sometimes to render the combination of dozens of enemies on the screen.