Loma is an unincorporated town, post office, and census-designated place (CDP) located in and governed by Mesa County, Colorado, United States.

[7][8] Agriculture became a dominant feature in Loma's early economy, enabled by the completion of the Kiefer Extension irrigation canal in 1899.

Verner Zevola Reed, known as "The Colorado Millionaire"", opened the Golden Hills ranch on 1,200 acres (490 ha) of land he had purchased 2 mi (3.2 km) north of Loma in 1907.

Reed intended on growing apples, and installed an underground irrigation system to water his orchards.

[8][9] A "reading room" was established in Loma in 1936 as part of an effort to provide rural citizens in Mesa County with free public library service.

[14] In the 1950s, a pipeline was constructed along an abandoned Uintah Railway track to carry a mixture of crushed gilsonite ore and water from Bonanza, Utah, to Loma.

[7][8][11] In July 2015, the Colorado Department of Transportation installed Loma's first signal light at the intersection of Highway 139 and Route 6.

Interstate 70 forms the southern edge of the Loma CDP, with access from Exit 15 (Colorado State Highway 139).

Loma has been described as having: A sense of openness that is created by farmsteads, viable agriculture, farm based businesses, small subdivisions, mixed housing types and lot sizes, single-lane farm roads, and two core villages [Loma and Mack] that are the focal points of the surrounding landscape.

The underpinnings of rural character is supported by this self chosen lifestyle of small town values, family, community, independence, responsibility, conservation, entrepreneurship, and a strong work ethic.

[16] The trail passes through the 123,430-acre (49,950 ha) McInnis Canyons National Conservation Area south of Loma.

[19] Law Enforcement is provided by the Mesa County Sheriff and the Colorado State Patrol.