[2] The London Clinic was established by a group of Harley Street doctors; the building was designed by Charles Henry Biddulph-Pinchard and officially opened in 1932 by the Duchess of York, who was accompanied by the Duke.

[6] The Second World War came close to home for the London Clinic with bombs falling in the Marylebone area and in Harley Street.

These included Archibald Sinclair Secretary of State for Air  and General Dwight D. Eisenhower Supreme Allied Commander Europe who both worked from the Clinic when they were patients.

[9] The London Clinic wartime Matron was Miss Jean Decima Jacomb who was born on 11 January 1894, the tenth child out of thirteen of an affluent family.

She was credited with establishing the highest nursing standards always displaying calm authority and maintaining an unfailing presence.

[14] Queen Elizabeth II opened a new cancer centre, built at a cost of £80 million, at the London Clinic in April 2010.

[20] In June 2021, following an unannounced inspection, the Care Quality Commission (CQC) used their enforcement powers to issue the clinic with a Warning Notice in respect of their failure to provide Good Governance.

[22] In 2022, the Competition and Markets Authority (CMA) issued an Official Reprimand, for the clinic's lack of transparency over a period of six years, for not disclosing part-time Consultants' referral payments, going back to 2015.