Lophognathus is a genus of large-bodied agamid lizards, consisting of two species — L. gilberti and L. horneri — both of which are endemic to northern Australia.

Along with several other closely related genera (e.g., Amphibolurus, Gowidon, and Tropicagama), these lizards are commonly referred to as "dragons".

Lophognathus are slender, slightly compressed, semi-arboreal lizards.

They occur in a variety of habitats, including sand dunes and arid regions, but frequently near watercourses.

The genus Lophognathus was originally named and described by John Edward Gray in 1842.