Prince of Biscari (Italian: Principe di Biscari) is a title in the Kingdom of Sicily, held by the head of one branch of the House of Paternò, a major Sicilian noble family, originally a cadet branch of the House of Barcelona.

The title was created by the grant of a Letters Patent from King Philip IV of Spain on 21 June 1633, which was bestowed upon the Baron of Biscari, Don Agatino Paternó Castello.

[1] He is known chiefly for having raised the fief of Biscari out of the marshy valleys subject to deadly malaria[2] and for marrying the daughter of the Baron Vincenzo Paternó Castello.

He married the heiress of Vincenzo Paternó Castello, named Maria la Restia, and accordingly for their culture and times, assumed the rank and style of the first Prince of Biscari.

[1] Their great-grandson, named Vincenzo, would become known for having restored the town, and especially the castle, after severe earthquake damage in 1693.