Established at Milsons Point in 1901, Loreto has a selective enrolment policy and currently caters for approximately 1,142 girls from Kindergarten to Year 12.

Adjacent properties were purchased over the years, including Coreena (previously owned by Alfred Milson) in 1921, The Hermitage in 1924, Thoms in 1952, and Araluen in 1975.

Government funding in the 1960s allowed for the building of St Joseph's wing, including science rooms and a library.

[8] The boarding school began its phasing out period in 1968, following an explosion which destroyed St Mary's (Thoms).

At the 2013 Spring Fair the library raised $3 000 for their sister school in Panighatta by selling handmade book related jewellery, in a stall named 'Read-Cycled'.

Sports offered to junior students include: Athletics, Basketball, Cricket, Cross country, Water Polo, Hockey, Netball, Rowing, Skiing, Soccer, Swimming, Tae Kwon Do, Tennis, Tildesley Shield Tennis, Volleyball and Touch football.