She married a fellow graduate student, Douglas Henry Fryer, and moved with him to New York, where "he became an instructor in the Columbia University psychology department and she enrolled in the PhD program, receiving her degree in 1924".
She found work in various vocations such as editing, writing for newspapers or professional journals, she also taught sociology and psychology at several universities, and was a research and consulting psychologist for several institutions.
But despite being mentally sound, Pruette's agnostic beliefs caused her some spiritual grief as she contemplated what was to become of her soul after her death, and within her last few years of life she is recorded as waking up in a feverish sweat numerous times yelling out, "Immortality is what I want!".
[9] Because Pruette lived through the transition from a homosocial to heterosocial society, aided in and witnessed many of the triumphs of feminism, she regarded the modern day woman as taking her rights for granted and being ignorant to the struggles of the women who came before her.
[10] Nearing the end of her life, Lorine Pruette urged women not to unquestioningly accept the social stigmas of the current society and to remember to use each other's help and support to press for change.