Considered a virtuoso guitarist, Lofsky is known for his collaborations with Oscar Peterson, Ed Bickert, and Kirk MacDonald.

He began playing rock music at school dances but later took an interest in jazz after hearing the album Kind of Blue by Miles Davis.

During the 1970s, Lofsky worked with Canadian musicians Butch Watanabe and Jerry Toth and visiting Americans Pepper Adams, Bob Brookmeyer, and Chet Baker.

Lofsky has also worked with Ed Bickert, Ruby Braff, Rosemary Clooney, Kirk MacDonald, Rob McConnell, Tal Farlow, Dizzy Gillespie, Johnny Hartman, and Clark Terry.

In the early-1980s, Lofsky began a musical association with saxophonist Kirk MacDonald, leading to the formation of a quartet.