A significant portion of the population consists of Mexicans of European descent, primarily from the criollos of Castillian, Extremaduran, Galician, Basque, and Andalusian origin, but also from early Portuguese and Sephardic Jews settlers and later immigrants from other parts of Europe.

[2] Their descendants allegedly still inhabit El Bajío intermixed with the remaining Chichimeca and migrating natives from other parts of Mexico (e.g. the Tlaxcaltec and the Totonac) who also helped the Spanish in their campaigns.

[2] Other sources also theorize that the Altos de Jalisco originated as a Sephardic Jewish community in the region during colonial times.

In Spain, a charro is a native of the province of Salamanca, especially in the area of Alba de Tormes, Vitigudino, Ciudad Rodrigo and Ledesma.

[22] It's likely that the Mexican charro tradition derived from Spanish horsemen who came from Salamanca and settled in Los Altos de Jalisco.

Some of Los Altos’ older architectural structures, both Pre-Hispanic and colonial, have been designated Pueblo Mágico or National Patrimony protected by Mexico's INAH for their historical, cultural or artistic significance.

The architecture in Los Altos is heavy influenced by European architects during the Spanish Colonial to early WWI era.