[2] On February 20, 1694, Don Francisco Berroterán, governor of the Province of Venezuela, declared Los Guayos "Town of Indians".

On June 6, 1710, the priest Mariano de Martí made "Los Guayos" a parish.

In 1751, inhabitants of Los Guayos joined the national uprising led by Francisco de León against the Compañía Guipuzcoana.

The Los Guayos river runs from the northeast to the southeast part of the town.

[4] The mayor of the Los Guayos Municipality is Anibal Jose Dose Rumbos, re-elected on November 23, 2008 with 52% of the vote.