Los Santos Zone (Spanish: Zona de los Santos) is a mountainous region in the San José Province of Costa Rica, in the center-south of the country.

It corresponds to a wide sector of a series of intermontane valleys composed by the cantons of Tarrazú, Dota and León Cortés Castro.

The nearby districts of San Cristóbal and Frailes, both of Desamparados canton, are under the socioeconomic influence of the zone.

[2] The region's economy and social fabric has been deeply shaped by emigration to the United States, which started in the 1960s.

[3] The zone has many tourist attractions due to the coffee production of the region, Los Quetzales National Park and the easy access through the Inter-American Highway, (Route 2) and close proximity to the Greater Metropolitan Area.