A fishing camp was located at the base of Lost Mountain for decades.

Aside from the mountain's unusual geological prominence, its only other cause for note occurred during the early 20th century, when a self-proclaimed religious leader, who referred to himself as the supreme deity, established a commune of his followers at the top of the mountain.

The mountain was part of a very busy setting due to the location of Kosoma, Oklahoma—an early boomtown turned ghost town—nearby.

The St. Louis and San Francisco Railway, whose tracks ran along the mountain's base, operated from the 1880s until 100 years later.

Oklahoma State Highway 2 now passes to the west of Lost Mountain, affording an excellent view of it and the river valley.