Lotoshino (Russian: Лотошино́) is an urban locality (an urban-type settlement) and the administrative center of Lotoshinsky District of Moscow Oblast, Russia.
It is the least populous administrative center of a district in Moscow Oblast.
Under the Russian Empire, it was a village within Volokolamsky Uyezd of Moscow Governorate, but did not even have a status of a volost center.
It became the administrative center of the district in 1929, when Moscow Oblast was founded.
In 1951, it was granted urban-type settlement status.