[1] Astorino was born in Pittsburgh to a family of mixed Italian and Serbian origin.
[2] He received a bachelor's degree from Penn State College of Arts and Architecture in 1969.
[5] Astorino was introduced to the international stage in 1996 when Gateway Clipper Fleet founder John E. Connelly introduced him as a prospective architect for the Domus Sanctae Marthae that Pope John Paul II wanted to build to house cardinals during the selection of popes.
[6] Astorino's firm designed the new Children's Hospital of Pittsburgh, completed in 2009 at a cost of $622 million.
[7] In December 2014, Astorino's firm was acquired by CannonDesign, which is based in Buffalo, New York.