The film stars Sam Worthington, Rosamund Pike, Bill Nighy, Édgar Ramírez, Toby Kebbell, Danny Huston, Ralph Fiennes, and Liam Neeson, with Jonathan Liebesman directing a screenplay by Dan Mazeau and David Leslie Johnson from a story by them and Greg Berlanti.

Writers Dan Mazeau and David Leslie Johnson were hired in June 2010 and director Jonathan Liebesman was brought on board in August 2010.

A sequel entitled Revenge of the Titans was planned for a 2013 release, but was cancelled due to Wrath's underperformance and too few ideas for a script.

After an encounter with three 30 ft. Cyclopes, the travelers eventually meet the now-mortal Hephaestus and reach the entrance of a labyrinth leading to Tartarus.

Aiming to retrieve Zeus' thunderbolt from Ares in order to defeat Kronos, Perseus challenges him to a duel.

Lily James appears as Korrina, a female warrior from Argos, while Matt Milne plays another Argive soldier.

[8] In April 2010 it was reported that director Louis Leterrier would not return to direct, but would be an executive producer on the second installment.

[9] In June 2010, Warner Bros. hired David Leslie Johnson and Dan Mazeau to write the screenplay, with Basil Iwanyk returning as the producer.

[11] In September 2010, Liebesman confirmed that Sam Worthington, Gemma Arterton, Ralph Fiennes, and Liam Neeson would be returning.

[12][13] However, Arterton did not reprise her role for unknown reasons, leaving her character, Io, dead in the film.

[14] In January 2011, it was reported that Édgar Ramírez and Toby Kebbell were in negotiations to play Ares and Agenor respectively.

Additionally, Hayley Atwell was on the shortlist of actresses screen testing for the role of Andromeda, played in the previous film by Alexa Davalos who left due to a scheduling conflict.

Other actresses being considered for Andromeda included Georgina Haig, Janet Montgomery, Dominique McElligott, and Clémence Poésy.

It was shot as a 2D movie and edited as a 2D film, and they decided to convert it with six or seven weeks to go until release, which is insane; the technology was not there.

[18] Wrath of the Titans premiered on March 26, 2012, at the AMC Lincoln Square Theater in New York City.

If Wrath of the Titans ultimately flops, then, it will do so in the exact form today's Hollywood prefers: safely, quietly, without much of a fuss.

"[28] Metacritic assigned the film an average score of 37 out of 100 based on 32 critics, indicating "generally unfavorable reviews".

[30] Todd McCarthy of The Hollywood Reporter called it, "A relentlessly mechanical piece of work that will not or cannot take the imaginative leaps to yield even fleeting moments of awe, wonder or charm".

[20] Roger Ebert, who gave the first film three stars, awarded Wrath with only two, remarking "It lacks a comprehensible story, and you won't need your CliffsNotes on the Greek myths.

You get an idea of who the major players are, and then they spend a modest amount of time shouting laughable dialogue at one another while being all but forced off the screen by special effects.".

[33] Richard Corliss of Time magazine wrote, "Wrath [of the Titans] radiates the straight-forward, straight-faced pleasures of the mytho-muscular epics, like Hercules and Jason and the Argonauts, produced in Europe a half-century ago".

[34] Owen Gleiberman of Entertainment Weekly commented, "For a movie that's basically all warmed-over pseudo-mythology and special effects, Wrath of the Titans is certainly more fun, in its solemnly junky way, than John Carter.

However, due to Wrath's disappointing critical reception and box office returns, the project was later shelved.

[36] In December 2013, producer Basil Iwanyk confirmed the sequel was not happening due to a lack of fresh ideas for the script.