Louis de l'Isle de la Croyère[a] (c. 1685 – 10 October 1741) was a French astronomer, who served the Russian Empire and became an academician of the Russian Academy of Sciences in Saint Petersburg.

He was invited to Russia in February 1726 by his brother Nicolas (1688–1768) who had arrived the previous year as the director of the cartography department at the Imperial Saint Petersburg Academy of Sciences.

Louis de l'Isle was made professor of astronomy and academician in January 1727.

He was named as the head of the first astronomical and geological expedition in Russia's European north.

As part of the academic component of the Second or Great Northern Expedition, in 1741 de l'Isle was with the Russian explorer Aleksei Chirikov on the ship St. Paul en route from Kamchatka to Alaska.