Louisa is a home-rule class city located in eastern Kentucky, United States, at the merger of the Levisa and Tug Forks into the Big Sandy River, which forms part of the state's border with West Virginia.

Virginia, Carolina and other English colonial-linked settlement attempts began as early as 1790 but did not take hold until 1818.

About 1792, Vancouver's Station, which had been destroyed by the Native Americans in 1790, on the tongue of land between the Levisa and Tug Forks of the Big Sandy, was reestablished.

Kentucky Route 3 passes through the center of Louisa on Madison Street; KY 3 leads northwest 7 miles (11 km) to Fallsburg and southeast up the valley of the Tug Fork and Rockcastle Creek 25 miles (40 km) to Inez.

[11] The climate in this area is characterized by relatively high temperatures and evenly distributed precipitation throughout the year.

[12] The bridge from Louisa, Kentucky to Fort Gay, West Virginia, is a rare multi-way T-bridge.

[13] "The Paveillon" (or more commonly known as "The Birdhouse") is a five story tall spire structure that serves as a gas station, rest stop, and a country music museum [14] along U.S. Route 23 as it passes through the western side of the city.

The structure was inspired by the Hotel del Coronado in San Diego, California and the Grand Floridian Resort in Orlando, Florida.

The Fred M. Vinson Birthplace is the historical boyhood home of the 13th Chief Justice of the United States, and the first jail to be built in Lawrence County.

[15] Every second weekend in September, Louisa hosts the regional Septemberfest that features several local and national acts performing for three days, as well as arts and crafts on the northwestern side of town, and the many food vendors featuring Southeastern cuisine.