She had three brothers, including John, Lord Hervey and Frederick, 1st Marquess of Bristol; and two sisters, Lady Mary Erne and Elizabeth Cavendish, Duchess of Devonshire.

Most of her time was spent with her mother, who sought to instill strong religious and moral principles; for example Louisa made clothes for a poor girl she was maintaining at school.

[2] In 1793, Louisa met Robert Jenkinson, a Member of Parliament and the son of Lord Hawkesbury, the future Earl of Liverpool.

Robert was appointed prime minister in June 1812, succeeding the assassinated Spencer Perceval,[6] and would remain in that post until after Louisa's death in 1821.

Although Lady Louisa often found the role of politician's wife tiring, she relished the excitement of attending functions and being close to great events.

[7] Loyal and supportive of her husband,[8] she took a keen interest in his political work, and sometimes helped him by copying confidential documents,[7] while his friend Thomas Lawrence thought Robert communicated much information to his wife and asked her opinion on many of his letters.

[9] In addition, Louisa involved herself in charity work, providing relief to the poor and infirm and helping to comfort the dying.

[8] The Liverpools employed architect John Soane to improve and extend the property,[11] where Louisa was hostess to a number of important visitors, including the King in 1805[12] and Tsar Alexander I of Russia in 1814.

[13] Lady Louisa was not strong physically and while she enjoyed her position, including attending official events and entertaining, she easily tired and was prone to colds and headaches.

[16] Louisa died at Fyfe House in London on 12 June 1821 aged 54, and was interred in the Jenkinson family vault at the Church of St Mary, Hawkesbury, Gloucestershire.