During the Civil War, at the relatively young age of 24,[1] Schuyler was appointed as the corresponding secretary in the Woman's Central Association of Relief (WCAR) in New York City.

[2] The mission of WCAR was to coordinate the efforts of the volunteers on the home front, including distribution of millions of dollars of supplies, and providing training materials.

[5] In recognition of her 40 years of activity in charitable work, she received in 1915 the honorary degree of Doctor of Laws from Columbia University.

[6] In 2000, the State Charities Aid Association was renamed the Schuyler Center for Analysis and Advocacy in her honor.

[4] Schuyler never married, living with her sister Georgina for most of her adult life.