The Louisburg Railroad was first chartered in 1881 and construction began in 1884 and it was completed in 1885.
By 1955, a local daily freight train was running the line six days a week.
The merged company was named the Seaboard Coast Line Railroad (SCL).
The Seaboard Coast Line operated the Louisburg Subdivision from 1967 to 1982.
[3] The Louisburg Branch was operated as a part of the Seaboard System Railroad's Norlina Subdivision from 1982 to 1985.