On 23 October 1670 in Cölln, she married the later Landgrave Frederick II of Hesse-Homburg, the famous Prince of Homburg.

This conversion brought him into closer relations with the princely houses in Brandenburg and Hesse-Kassel, who were also Calvinist.

Louise Elisabeth's sister Maria Amalia married Landgrave Charles of Hesse-Kassel in 1673.

This relationship allowed Frederick to join the Prussian army and become commander of all the troops of the Electorate only two years later, in 1672.

The Calvinist Louise Elisabeth played a significant role in the settlement of displaced Huguenots and Waldenses in Friedrichsdorf and Dornholzhausen in as well as in the formation of Calvinist congregations in Weferlingen and Bad Homburg.