In 2003, Griffiths was one of the first of four students chosen by the public to appear on the second series of the BBC TV show Fame Academy when it was revealed in the press that she was the girlfriend of Formula One driver Jenson Button.

Although Griffiths did not get a recording contract after the show, one of the songs she co-wrote with fellow student Alistair Griffin, "A Heart Can't Lie", was included on his debut album Bring It On which reached No.

[2] In 2006 Griffiths made her film debut with her role of Melissa in the horror movie The Devil's Chair , directed by Adam Mason.

In April 2008, Griffiths booked her first lead role in the dark comedy feature The Revenant opposite David Anders, Jacy King, and Chris Wylde.

Griffiths starred in All's Faire in Love, released in October 2011, opposite Christina Ricci, Matthew Lillard, Cedric the Entertainer, and Ann-Margret.