One of Louise Henriette's cousins, Louis Jean Marie de Bourbon, Duke of Penthièvre, son of Louis-Alexandre de Bourbon, Count of Toulouse, and heir to the Penthièvre fortune, had proposed marriage to her, but her mother's choice fell upon the heir of the more prestigious House of Orléans.

As a result, on 17 December 1743, at the age of seventeen, Louise Henriette married her second cousin, the Duke of Chartres, Louis Philippe d'Orléans, in the chapel of the Palace of Versailles.

The conflict began between the sisters Louise-Françoise de Bourbon, Dowager Princess of Condé (Louise Henriette's grandmother) and Françoise-Marie de Bourbon, Dowager Duchess of Orléans (Louis Philippe's grandmother), both of whom were legitimised daughters of Louis XIV and Madame de Montespan, when their father gave Françoise-Marie a dowry upon her marriage into the House of Orleans that was twice as large as the dowry he gave Louise-Françoise upon her marriage into the House of Bourbon-Condé.

[3] Among her extramarital affairs, she is said to have had a relationship with the Count of Melfort whom she met at the Château de Saint-Cloud after the birth of her son.

However DNA testing in a 2014 established the Y-chromosome haplogroup and ySTR pattern of the House of Bourbon, and has indeed confirmed the biological legitimacy of Louise Henriette's eldest son, Philippe-Égalité.

The latter is a direct male line descendant of Philip I, Duke of Orleans - a younger brother of Louis XIV and the ancestor of Louise Henriette's husband.

All 3 testers were a genetic partilineal match on a ySTR comparison, and were assigned to sub-haplogroup R1b1b2a1a1b*(R-Z381), now deemed the upstream patrilineal snip of the House of Bourbon.