Louise Independent School District is a public school district based in the community of Louise, Texas (USA).

In 1990 the Louise schools counted 448 students and 36 faculty members.

The high school competes in football, volleyball, basketball, baseball, softball, power lifting, track, cross country, golf, tennis.

The campuses and the district meet the Annual Yearly Progress required by the federal No Child Left Behind laws.

In 2009, the school district was rated "academically acceptable" by the Texas Education Agency.