Delos Reyes was 8 years old when she started her acting career in the show Ang TV 2 using her real name Grace.

She was then a cast in Ang Iibigin ay Ikaw and had been a contract artist of GMA until early 2004 and stopped to focus on her studies.

She also played a lead role in the Peque Gallaga indie film Agaton and Mindy, which earned her a Best New Movie Actress nomination from PMPC.

Delos Reyes was also a cast in My Beloved headlined by Marian Rivera and Dingdong Dantes and got her first break in 2012 as she played the lead role Elize in the GMA primetime drama One True Love with Alden Richards.

Delos Reyes made a TV comeback as Pepay in GMA's Afternoon Prime drama Magkaibang Mundo in 2016 and starred in Baka Bukas.