Near the east end of its route, LA 106 passes through an interchange with Interstate 49 (I-49) between Opelousas and Alexandria in the southwest corner of Avoyelles Parish.

It proceeds in a general eastern direction along Beaver Road for 8.6 miles (13.8 km), making a long curve to the south and back to the east for much of the distance.

It then skirts the northern border of Pine Prairie briefly and intersects LA 13 (Veterans Memorial Boulevard), which heads to Mamou on the south.

After heading in a general northeast direction along St. Landry Highway for 4.5 miles (7.2 km), LA 106 reaches a point known as Bayou Chicot.

LA 106 then crosses the Acadiana Railway (AKDN) tracks and takes a sharp turn to the north out of town.