[2] The route heads north along the west bank levee of the Atchafalaya River into Krotz Springs, where it crosses the Union Pacific Railroad (UP) line at Main Street.

LA 105 then passes underneath the twin spans of the US 190 Atchafalaya River bridge between Baton Rouge and Opelousas.

Louisiana Highway 108 (LA 108) runs 24.87 miles (40.02 km) in a general east–west direction from I-10 in Vinton to US 90 in Sulphur, Calcasieu Parish.

Louisiana Highway 110 (LA 110) runs 25.15 miles (40.48 km) in a northwest to southeast direction from US 190 in Merryville to the concurrent US 171/US 190 in Longville, Beauregard Parish.

After passing the local high school, the route turns to the southeast and travels 9.6 miles (15.4 km) to a junction with LA 27 at Singer.

[8][9][10] At Dry Creek, a junction with LA 394 provides access to the recreational area around Bundick Lake.

[6][8][12] At Union Hill, the highway crosses LA 112 once again and proceeds eastward through the southern edge of the Kisatchie National Forest.

Near the end of its route, LA 113 zigzags to the south and east into the town of Glenmora, terminating at US 165 between Oakdale and Alexandria.

[18] Louisiana Highway 120 (LA 120) exists in two sections, running a total of 36.24 miles (58.32 km) in an east–west direction.

[22] Louisiana Highway 125 (LA 125) runs 12.49 miles (20.10 km) from US 165 in Tullos to US 165 northeast of Olla.

[25][27][28] Louisiana Highway 129 (LA 129) runs 32.51 miles (52.32 km) in a north–south direction from a point on the Red River south of Acme to US 84 west of Ferriday, Concordia Parish.

Louisiana Highway 142 (LA 142) runs 8.76 miles (14.10 km) from US 425 north of Bastrop to AR 133 at Arkansas state line northwest of Beekman.

[38] Louisiana Highway 148 (LA 148) exists in two sections, running a total of 15.65 miles (25.19 km) in an east–west direction.

[41] It serves as the principal north–south thoroughfare through the town and connects Grambling State University to both I-20 and the parallel US 80.

LA 149 heads north as an undivided two-lane highway through a rural residential area.

After a short distance, the highway widens to four lanes as it begins to pass through the middle of the Grambling State University campus.

It then crosses the Kansas City Southern Railway (KCS) tracks via an overpass and intersects LA 150 (West Martin Luther King Jr. Avenue).

LA 149 then curves to the northeast and passes through an interchange with I-20 at Exit 81, leading toward Monroe and Shreveport.

[44] LA 149 was created in the 1955 Louisiana Highway renumbering,[45] largely following a parallel alignment along Main Street.