It spans a total of 2.2 miles (3.5 km) largely over a former alignment of both U.S. 11 and U.S. 90 in the town of Pearl River.

LA 3081 then turns northeast alongside the interstate, looping back southwest underneath the I-59/U.S.

The portion of LA 3081 running along Main Street through Pearl River was originally part of the Old Spanish Trail, designated as State Route 2 from 1921 until the 1955 Louisiana Highway renumbering.

In 1964, concerns over the safety of the U.S. 11 West Pearl River Bridge, built in 1926,[1] led to its closure, and U.S. 11 was detoured onto the recently-opened, parallel I-59.

)[3] The West Pearl River Bridge was reconditioned in 1968 to serve local traffic until the interchange of I-59/U.S.