It is essentially the middle link in a route connecting the Slidell area with the Washington Parish city of Bogalusa.

After traveling along the west side of the town's corporate limits, LA 41 heads north through the small unincorporated communities of Hickory, Talisheek, and Bush.

In the late 1960s, a local road around the west side of Pearl River was improved as part of a realignment of LA 41, facilitating access to southbound I-59.

LA 41 heads northwest on Watts Road as an undivided two-lane highway with a center turning lane and proceeds to make a loop around the west side of town.

North of Hickory, the highway continues through a thin ribbon of scattered residential development as it winds between the Pearl River system to the east and rural St. Tammany Parish to the west.

Northbound LA 21 proceeds straight ahead on the four-lane highway toward the Washington Parish city of Bogalusa.

[11][12] LA 41 was created in the 1955 Louisiana Highway renumbering, applying a continuous route number between Pearl River and Bush.

In the late 1960s, a slight bypass of Pearl River was created by improving the old Military Road around the west side of town, facilitating through traffic bound for I-59 south.

[14][15] The original alignment was retained as LA 41 Spur, a designation which also extended across US 11 to an interchange facilitating access between Pearl River and northbound I-59.

After traveling southeast for 1.4 miles (2.3 km), the highway turned east onto Pine Street near the town hall and proceeded a short distance to a junction with LA 3081.

LA 41 Spur then crossed the Norfolk Southern Railway (NS) tracks at grade to reach ramps serving southbound I-59/US 11 at Exit 5A.

LA 41 Spur proceeded to make a nearly one-mile-long (1.6 km) loop underneath the I-59/US 11 bridge across the West Pearl River to access the northbound ramps.