After briefly traveling northward, LA 301 curves to the east through a sparsely populated area opposite the town of Jean Lafitte.

[3][4][7] It is an undivided two-lane highway for its entire length and is classified as a rural local road by the Louisiana Department of Transportation and Development (La DOTD).

After about 3.0 miles (4.8 km), the route curves more to the east and traverses an area of light suburban development until it reaches its northern terminus at a junction with LA 20 in the small community of Chackbay.

The majority of the route is classified as a rural minor collector by the Louisiana Department of Transportation and Development (La DOTD).

It then turns sharply to the northwest and travels alongside Bayou Gauche, passing a series of fishing camps and boat houses.

After 2.5 miles (4.0 km), LA 306 curves to the north to follow a drainage canal and passes alongside a suburban neighborhood.

The majority of the route is classified as a rural minor collector by the Louisiana Department of Transportation and Development (La DOTD) with the average daily traffic reported as 3,700 vehicles in 2013.

[25] LA 306 was created in the 1955 Louisiana Highway renumbering,[8] and its route has remained the same to the present day apart from the smoothing of a sharp curve west of the Grand Bayou Canal bridge.

After 9.0 miles (14.5 km), LA 307 curves to the west and crosses a vertical lift bridge over Bayou Boeuf just south of Lac des Allemands.

It then proceeds through the communities of Bayou Boeuf and Kraemer, the houses of which line the narrow strip of dry land traversed by the highway.

Proceeding northward, LA 309 immediately crosses the BNSF/Union Pacific Railroad tracks at grade and passes underneath the elevated US 90.

LA 309 crosses into Lafourche Parish shortly afterward and continues through uninhabited swamp for roughly half of its route.

The section through Brule is classified as an urban collector by the Louisiana Department of Transportation and Development (La DOTD) with the average daily traffic in 2013 reported as 2,400 vehicles.

The uninhabited area south of Brule is classified as a rural minor collector with a lower daily traffic volume of 1,590.

[8] It became defunct in March 2013 when a new six-lane vertical lift bridge was completed 0.6 miles (0.97 km) downstream on an extension of LA 657.

It heads northwest along Little Bayou Black Drive for a few blocks in a concurrency with LA 311 before turning north onto Lafayette Street.

It follows the east bank of Bayou Du Large through the communities of Theriot, Sunrise, and Crozier before reaching a bridge over the Gulf Intracoastal Waterway just south of Houma.

The highway travels alongside the remains of Bayou Blue, the location of the parish line, and passes through a diamond interchange with US 90 at Exit 204.

The route proceeds along the west bank of Bayou Sale in a general northeastern direction through the sparsely populated communities of Gordy and Ellerslie.

After 10.1 miles (16.3 km), LA 317 crosses a bridge over the Gulf Intracoastal Waterway then passes between a pair of chemical plants at North Bend.

5.0 miles (8.0 km) later, at a point known as Bayou Sale, LA 317 enters into an interchange with US 90, which connects with Lafayette to the northwest and Morgan City to the east.

Beginning at a private road in Cypremort Point, it heads northeast passing rows of houses affronting Vermilion Bay.

After passing the access road to Cypremort Point State Park, the density of houses lining the highway diminishes in favor of more swampland.

LA 319 climbs in elevation to cross the Louisa Bridge, a high double-bascule drawbridge opened in 2005 over the Bayou Cypremort, part of the Gulf Intracoastal Waterway.

[52] LA 322 was created in the 1955 Louisiana Highway renumbering,[8] the north–south portion of its route having originally followed a parallel alignment prior to the replacement of the Sterling Bridge in 1971.

In Baldwin, LA 326 travels north-northeast along Charenton Road paralleling Bayou Teche and passing farmland and many houses.

At Martin Luther King Road, the highway makes a slight curve before heading back towards the north towards the downtown area.

After intersecting LA 324 at Convent Street, the highway ends shortly thereafter coinciding with a sharp bend in the road and in the bayou.

The highway widens to a four-lane divided arterial, shortly before reaching its northern terminus at LA 3073 (Ambassador Caffery Parkway), which connects with US 167 to the northwest.

It is generally classified by the Louisiana Department of Transportation and Development (La DOTD) as a rural major collector south of Youngsville and as an urban minor arterial through the Lafayette area.