Beginning at a point on the Texas State Line, near Waskom, through Greenwood, Shreveport, Grand Cane, Mansfield, Sodus, Belmont, Marthaville, Robeline, Natchitoches, Montgomery, Colfax, ALexandria, Lecompte, Bunkie, Melville, Rosedale, Port Allen, Baton Rouge, Hope Villa, Burnside, Convent, Kenner, Shrewsbury, Protection Levee at South Claiborne Avenue, New Orleans, Louisiana, South Claiborne Avenue both sides to Canal Street, North Claiborne Avenue both sides to Poland Avenue, St. Claude Avenue, both sides to St. Bernard Parish Line, Mereaux, Violet, Poydras, Dalcour, Phoenix, Point-a-la-hache to Fort St. Philip.

Also, a two-mile section between Norco and Montz was eliminated in 1935 when the parallel Airline Highway bridge across the Bonnet Carré Spillway was opened.

It used the current route of US 71 to Bunkie, with a short section over a one-lane truss bridge that was bypassed in the mid-1930s.

North of Cheneyville, it used US 71 and parts of some bypassed roads to Chambers, then Old Baton Rouge Highway to Alexandria.

(Stainaker Street is a small, severed portion of the original route near the junction of US 71 and LA 3225.)