Written and produced by White, the track is an Americana song and a blues ballad with lyrics that explore love using violent imagery.

It features vocals from White and Ruby Amanfu, and its instrumentation includes the bass clarinet, the Wurlitzer electric piano, and the acoustic guitar.

[3][4] On January 30, 2012, White announced his debut album Blunderbuss along with the release of its lead single, "Love Interruption"; a free stream of the song was offered on his website.

[11] The song is two minutes and 36 seconds in length,[8] and it consists of White harmonizing with Ruby Amanfu, creating a melody that utilizes elements of country soul.

[7][12] It features the bass clarinet and a prominent Wurlitzer electric piano—played by Emily Bowland and Brooke Waggoner, respectively—while acoustic guitar chords work alongside the piano to drive the song.

[13] Pitchfork's Ryan Dombal viewed the line "I won't let love disrupt, corrupt, or interrupt me anymore" as an indication that the song is "a form of self discipline" rather than "some masochistic fantasy".

[18] Jem Aswad of Billboard described "Love Interruption" as "an unusual but tantalizing lead track" and concluded that it "leaves you lusting for more.

"[19] Rebecca Schiller of NME described the song as "a drumless, minimalist affair based on the chord progression of the Beta Band's 'Dry The Rain'".

[13] Citing the song's instrumentation, Michael Roffman of Consequence of Sound said that "Love Interruption" "didn't necessarily relive those feelings of seeing" the White Stripes.

[21] Schiller found that the "jolliness" on songs produced under the Dead Weather and the Raconteurs is absent on "Love Interruption", as is any "trademark [White] riffing".

[22][23] Described by Billboard's Jillian Mapes as a "hazy, self-directed performance clip",[24] the video consists of White and Amanfu singing "Love Interruption" alongside a backing band.

On the March 3, 2012 episode of Saturday Night Live, White performed "Love Interruption" with Amanfu and his all-female backing band the Peacocks.