Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic[4] antipsychotic medication used primarily in the treatment of schizophrenia.

[6] The US Food and Drug Administration (FDA) has approved loxapine inhalation powder for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults.

[7] A brief review of loxapine found no conclusive evidence that it was particularly effective in patients with schizophrenia.

[8] A subsequent systematic review considered that the limited evidence did not indicate a clear difference in its effects from other antipsychotics.

[12] At lower dosages its propensity for causing EPS appears to be similar to that of atypical antipsychotics.