The program participated in the first interracial American basketball game played south of the Mason–Dixon line at Hurt Gymnasium on February 12, 1952, a 65–63 win over Morgan State.

The only player in the program's Division I history to have reached the National Basketball Association (NBA) is Mike Morrison, a four-year letterman from 1985 to 1989.

The first time was in 1993–94 with an 80–75 win over Manhattan at Knickerbocker Arena and Tracy Bergan earning conference tournament Most Valuable Player (MVP) honors.

The Greyhounds' next conference title came 18 years later in 2012 with MVP Erik Etherly spearheading a 48–44 victory over Fairfield at MassMutual Center.

Smith, an assistant coach under Patsos for six seasons, was promoted to lead the Greyhounds into the Patriot League on April 12, 2013.

[9] Tavaras Hardy, an assistant coach on Josh Pastner's staff at Georgia Tech for two years, was appointed as Smith's successor 20 days later on March 28.

[10] His third campaign at Loyola ended with the Greyhounds advancing to its first Patriot League Championship Game in an 85–72 loss at Colgate on March 14, 2021 despite entering the tournament as the No.