Luc Van den Brande (born 13 October 1945) is a Flemish politician, member of the CD&V and was Minister-president of Flanders from 21 January 1992 until 13 July 1999.

He took the initiative to create the Flanders Institute for Biotechnology (VIB).

On 6 February 2008 he became President of the European Union's Committee of the Regions for a period of two years.

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