Born in Goiânia, Goiás, Luca Meirelles joined Santos' youth setup in 2018, aged ten, after playing in a football school in his hometown.

[1] He signed his first professional contract with the club on 20 July 2023, after agreeing to a three-year deal.

[2] On 12 November 2024, Luca Meirelles renewed his link with Peixe until December 2029,[3] and was promoted to the main squad two days later.

[4] He made his professional debut on 17 November, coming on as a late substitute for Giuliano in a 2–0 home loss to CRB, as the club was already champions.

[6] He played for the nation in the Cascais Luso Cup, scoring in all three matches of the competition,[7] and notably netting a hat-trick in a 16–1 win over São Tomé and Príncipe.