Cifarelli got her start recording in studios in New York, eventually forming her own band, Drill, along with future Black Label Society bass guitarist John DeServio.

Drill released one self-titled album, spawning two music videos and getting a third song featured in the movie Empire Records.

The youngest of four children, she grew up surrounded by music and art, developing a love for singing, songwriting and performing at an early age.

Cifarelli's first vocal coach, Tanya Travers, whom she found in the Village Voice classified ads at fourteen, introduced Cifarelli to her first songwriting collaborator Dan Wise, who would later go on to produce such notable artists as Run-DMC, The New York Dolls, Ani Difranco, 22 Brides, John Mayor and The Scissor Sisters.

Since the reformation of KMFDM, Cifarelli has been a featured vocalist and co-writer on every album since 2002 and has played 456 shows with the band as of January 2020.