Born in Albano Laziale, at young age Ocone moved to Rome to study acting, following courses held by Francesca De Sapio and Lucilla Lupaioli.

[1] She had her breakout in 2002, when she replaced Paola Cortellesi as comedian and impersonator in the Gialappa's Band comedy show Mai dire domenica.

[1] After appearing in other Gialappa's Band shows, in 2005 she joined the cast of Quelli che... il Calcio, where she stayed until 2009, and where eventually returned in the 2015–16 season.

[4] As an actress, Ocone appeared in numerous films, television series and stage plays.

[1] In 2022, she dubbed Zee in the Italian version of The Ice Age Adventures of Buck Wild.