Deciding for a career in experimental biological research, Lison started to work in histology, developing a number of new techniques for dyeing specific substances present in a slice of tissue.
Before the advent of radiolabeling, this was the only group of techniques which could infer function based on biochemical activity and it represented a great promise not only for basic science, such as physiology and pharmacology, but for pathology and laboratory diagnosis of diseases, as well.
Europe was living through the difficult post-war years and the concept proposed by Vaz was revolutionary and intrinsically motivational for Lison and other Europeans who had accepted similar invitations.
Dr. Lison became a full professor and chairman with the thesis titled "Influence of Fixative Agents on the Histochemical Reaction of Amine Groups", a very important work for neurochemistry.
A scientific award and the main auditorium of the School of Philosophy, Science and Letters of Ribeirão Preto, and a street in the campus of the University of São Paulo were named after him.