[1][2] The museum is dedicated to the lives and careers of Lucille Ball and Desi Arnaz.

[3] In addition to re-created sets, including the series' iconic living room,[2] the museum showcases the work of Desilu Studios in an adjacent building,[4][5] houses the couple's artifacts and memorabilia including Ball's Emmy Awards, and an event facility dubbed the Tropicana Room, a recreation of Ricky Ricardo's nightclub.

[1] Formerly, each May, the museum celebrated Lucy-Desi Days, which featured several events including panel discussions with those closest to Ball and Arnaz.

In the spring of 1989, Ball was meant to attend the commencement ceremony at Jamestown Community College and receive an honorary degree from the institution, and during the same weekend she planned to attend the Lucille Ball Festival of New Comedy, which she had developed in cooperation with the Arts Council of Jamestown,[6] but she died shortly before the scheduled event.

[5][3] Past festivals have featured Ray Romano, Ellen DeGeneres, Lewis Black, Billy Gardell, Jay Leno, Bill Engvall, Joan Rivers, Paula Poundstone, Kathleen Madigan, Tammy Pescatelli, and many more.