The film stars Mila Kunis, Finn Wittrock, Scoot McNairy, Chiara Aurelia, Justine Lupe, Thomas Barbusca, Jennifer Beals, and Connie Britton.

As she prepares to marry her fiancé, Luke Harrison, Ani meets with Aaron Wickersham, a documentary director who wants to make a short film about the school shooting she survived as a teenager.

In flashbacks to 1999, Ani is seen joining the prestigious Brentley School, where she quickly befriends a clique of popular students, including Dean and his friends Liam and Peyton.

Flashbacks see young Ani struggling to deal with the trauma of what happened to her, and not long after, the school shooting took place, perpetrated by Arthur and his friend Ben.

Back in 2015, at the publishing of his new book, Ani meets with Dean, who shows little remorse for what he did and threatens to recapitulate his story of her participation in the shooting if she tells anyone.

In August 2015, it was announced Lionsgate had acquired film rights to Luckiest Girl Alive by Jessica Knoll, with Reese Witherspoon set to produce under her Pacific Standard banner.

[3] In July 2021, Finn Wittrock, Scoot McNairy, Chiara Aurelia, Thomas Barbusca, Justine Lupe, Dalmar Abuzied, Alex Barone, Carson MacCormac, Jennifer Beals, and Connie Britton joined the cast.

The website's consensus reads: "Luckiest Girl Alive means well and Mila Kunis does strong work in the central role, but those positive points are overshadowed by a treatment that risks trivializing its themes.