[3] Bryce started her career at the Walter and Eliza Hall Institute of Medical Research after college.
[5][6] During World War II, Bryce held the rank of major in the Australian Army Medical Corps[7] and was invited in 1944 to the US with Marjorie Bick to study developments in blood transfusion,[8] then again with Bick in 1945, arriving on the S.S. Kanangoora in March[9] to visit the Hooper Research Foundation in Los Angeles then to New Orleans and Washington,[10] attending a conference of the blood substitute committee of the National Research Council.
[12][13] She reported on the mass production methods at the Cutter Laboratories of packing and shipping plasma and whole blood to be parachuted into the Pacific war zones.
[11] Their research coincided with a plan to expand the Blood Bank into a new floor of the Royal Melbourne Hospital.
[15] Bryce retired from active involvement in the Blood Bank in 1954, but continued to hold her title as honorary chair of the transfusion committee until 1966.