It operates worldwide air freight and logistics services and is headquartered at Frankfurt Airport, Lufthansa's main hub.

In 2002 the special logistics company time:matters was founded, which was sold in the meantime, but is now again a wholly owned subsidiary of Lufthansa Cargo.

[9] This venture operated a fleet of six Boeing 747 freighters that flew to destinations that include Frankfurt, Chennai, Shanghai, and Chengdu.

[10] In May 2011, Lufthansa Cargo opened another hub at Rajiv Gandhi International Airport in Hyderabad, India, to transport temperature-sensitive goods, especially pharmaceuticals, between South East Asia and Europe (and onwards to the United States).

[13] In September 2020, Lufthansa Cargo confirmed it was retiring its remaining McDonnell Douglas MD-11F during 2021 despite the grown freight demand in the wake of the COVID-19 pandemic.

[15] In June 2024, Lufthansa Cargo announced the inauguration of its first freighter services from Munich Airport with scheduled flights to Istanbul.

[19] Over the years, the following aircraft types were operated:[citation needed] Media related to Lufthansa Cargo at Wikimedia Commons