Tagle is the Cardinal-Bishop of San Felice da Cantalice a Centocelle (pro hac vice) and also serves as the President of the Catholic Biblical Federation, Grand Chancellor of the Pontifical Urbaniana University, and as a member of various departments and dicasteries in the Roman Curia.

[15] Florencio was injured by a bomb explosion during the Second World War; Tagle's grandmother made a living by running a local diner.

He wrote his dissertation under the direction of Joseph A. Komonchak on "Episcopal Collegiality in the Teaching and Practice of Paul VI".

[18] In Komonchak's estimation, Tagle was "one of the best students I had in over 40 years of teaching" and "could have become the best theologian in the Philippines, or even in all of Asia" had he not been appointed bishop.

After ordination, he held the following positions: associate pastor of San Agustín Parish – Méndez-Núñez, Cavite (1982–1984), spiritual director (1982–1983) and later rector (1983–1985) of the diocesan seminary of Imus.

After studies in the United States from 1985 to 1992, he returned to Imus and was Episcopal Vicar for Religious (1993–1995) and parish priest and rector (1998–2001) of Nuestra Señora del Pilar Cathedral-Parish.

[22] Pope John Paul II appointed Tagle to the International Theological Commission, where he served from 1997 to 2002 under its President, Cardinal Joseph Ratzinger.

[23] During his ten years in Imus, he made a point of living simply, owned no car, and invited the destitute to join him for a meal.

[24] He said:[25]To respond to the hunger for the Eucharist, priests say many Masses, accept multiple intentions and send lay ministers for the service of the Word with Communion....

How many defenseless people are being sacrificed to the god of national security?Pope Benedict XVI appointed Tagle the 32nd Archbishop of Manila on October 13, 2011, to succeed Cardinal Gaudencio Rosales.

[33] He was installed as archbishop on December 12, 2011, the feast day of Our Lady of Guadalupe and the tenth anniversary of his episcopal consecration.

Tagle discussed the way the sex-abuse crisis manifests itself in Asia, where it is more common for priests to violate their vows of celibacy by taking mistresses than to engage in the sexual abuse of minors.

[39][40] On August 4, 2012, Tagle delivered a speech at a prayer rally against the Reproductive Health Bill, which included provisions for the funding and distribution of birth control information and devices; contraception is customarily considered abortion in the Philippines.

[5] He advocated for the recognition of women's rights by recognizing their valued role as mothers and wives, deserving of genuine love and respect as reflections of God and a gift to mankind.

I believe the Church should contribute in the public square but we in Asia are very particular about the mode ... so you may be saying the right things but people will not listen if the manner by which you communicate reminds them of a triumphalist, know-it-all institution.

While awaiting for the date of assuming his new position, he served as the apostolic administrator of the metropolitan see on his last two months as Archbishop of Manila from December 8, 2019 to February 9, 2020.

[54][55][56] Tagle led the National Consecration to the Immaculate Heart of Mary at the San Fernando de Dilao Church on June 8, 2013.

[11][57]Following the publication of Pope Francis' encyclical Laudato si', Tagle launched a campaign in the Philippines to collect signatures for a petition against anthropogenic global warming caused by carbon dioxide emissions.

[84][85] Due to the enforcement of the Apostolic Constitution Praedicate Evangelium on June 05, 2022, many changes have been made to the Roman Curia.

Tagle was inducted to the Legion of Honour at Villa Bonaparte on February 15, 2024, by French Ambassador to the Holy See Florence Mangin, who gave him the insignia for the rank of “Officer”.

Tagle received the award in the presence of Philippine Ambassador to the Holy See Myla Grace Ragenia C. Macahilig, Gerard Timoner III, Nathaniel Imperial and Fr.

The coat of arms has adopted a different marshalling (division) in order to arrange the achievements in the shield (elements) in a heraldically correct manner.

It is surmounted by the white (Argent) monogram of the Blessed Virgin Mary, crowned and encircled by twelve golden stars.

The triangular green (Vert) base of the shield is charged with a yellow gold (Or) carpenter's square superimposed on two white (Argent) lilies with stalk and leaves.

Issuing out of the base of sinister side, a Corinthian Pillar Or surmounted by the monogram of the Blessed Virgin Mary Argent, crowned and encircled by twelve stars, all of the first.

[94] Its principal editors, Alberto Melloni and Giuseppe Alberigo, are identified with the Bologna School of ecclesiastical history which views the Second Vatican Council as a "rupture" with the past, a position criticized by Pope Benedict XVI and others, who hold that Vatican II represents "continuity" with the past.

[95] Tagle's contribution, written in 1999 when he was not yet a bishop, was a 66-page chapter in the fourth volume of the History called "A November Storm: The 'Black Week'" which covered the final days of the Council's third session in 1964, when several actions by Pope Paul VI caused alarm among reform forces.

In 2005, Archbishop Agostino Marchetto, Secretary of the Pontifical Council for the Pastoral Care of Migrants and Itinerants, a "continuity" advocate, assessed Tagle's chapter as "a rich and even comprehensive study", but called it "unbalanced, journalistic, and lacking objectivity expected of a true historian".

[99][b] The Vaticanologist John L. Allen Jr. reported that Cardinal Marc Ouellet, the Holy See's prefect for the Congregation for Bishops and protégé of Pope Benedict XVI, maintains his "full support" for Tagle.

He is also the Tuesday presenter of Kape't Pandasal ("Coffee and Prayer", a pun on the Filipino term kape't pandesal or "coffee and salted bread"), an early morning religious inspirational program partly produced by the same media arm, broadcast on TV Maria, DepEd ALS, and previously on ABS-CBN, and now streaming in YouTube.