Guzmán was born in Cayey, Puerto Rico, and was raised in New York City's Greenwich Village and the surrounding Lower East Side neighborhood.

[4] Guzmán graduated from Greendale Community College, and shortly after began his career as a social worker and moonlighted as an actor, eventually becoming heavily involved in street theater and independent films.

In 2010, he starred in HBO's How to Make It in America and appeared in a comical series of Snickers commercials that played during that year's Super Bowl.

[12] In 2018, Guzmán, along with New York Yankees all-star Bernie Williams, appeared in a season six episode of Jon Taffer's Bar Rescue, offering assistance not only to the El Krajo Tavern in Loiza, but the town's community center, after it was devastated from Hurricane Maria.

During Telegramgate, Guzmán was interviewed by MSNBC for his opinions on the situation in Puerto Rico and he expressed that "Ricky had to go" and that corruption on the island was a major problem that he hoped would be solved.