Her parents arrived as newlyweds in Entre Ríos, Argentina, in 1872, and moved to Paysandú, Uruguay, in 1878, before finally settling down in Montevideo in 1887.

The Luisi-Janicki clan was a family of workers and educators that developed in an environment of resistance and rebellion, and tended to think more liberally for their time.

She was also a Spanish professor in the Women's Section of Secondary Education and taught literature and oration in the María Stagnero de Munar Institute.

Criticism has focused on the classics employed in her verse and the intellectual values expressed in her poetry; she is grouped with the other three Uruguayan women of the modernist movement (modernismo): María Eugenia Vaz Ferreira, Juana de Ibarbourou and Delmira Agustini.

Luisa's philosophically inclined poetry and her rigorous critical works quickly reached an international public platform in Buenos Aires and in Barcelona and is studied in Madrid and in Paris.