[13] Acuña opened the 2022 season with the Hickory Crawdads of the High-A South Atlantic League, hitting .317/.417/.483 with eight home runs, 29 RBIs, and 28 stolen bases over 54 games.

[18] On July 30, 2023, the Rangers traded Acuña to the New York Mets in exchange for Max Scherzer and cash considerations.

[24] He recorded his first major league hit, a single to center field off of pitcher Taijuan Walker in the fourth inning.

[25] On September 17, during a game against the Washington Nationals, Acuña hit his first major league home run off of pitcher Joe La Sorsa, leading the Mets to a 10–1 victory.

His father, Ronald Sr., played in minor league baseball for three organizations, and, in 2022, his younger brother Bryan was signed by the Minnesota Twins.