At the same time Simonis started his musical career in Dutch punk and experimental bands such as Demogorgon, Dull Schicksal, Morzelpronk, Trespassers W and later Aa Kismet, Vril (both with Bob Drake), Static Tics, Coolhaven and became involved with the venues The Jazz Bunker and Dodorama.

From the mid-1990s on, Simonis started doing projects with a large series of experimental musicians such as Pierre Bastien, Eugene Chadbourne, and Anne La Berge.

VRIL is a collaboration of Chris Cutler, Bob Drake, Lukas Simonis and Alan Jenkins.

In 2006 the CD Collaborations was released on which Simonis works with Anne La Berge, Greg Malcom, Henk Bakker, Hilary Jeffery, Huib Emmer, Julia Eckhardt, Paolo Angeli, Paul Dunmal, and Rohan Thomas.

Ornament & Crime Arkhestra consisted of Alain Neffe, Han Buhrs, Harald Ingenhag, Lukas Simonis, Nadine Bal, Viola Kramer.