Luke Murrin (died after 1885) was an American politician who served as the 2nd Mayor of Cheyenne, Wyoming, and was the first following its chartering.

[2] On June 3, 1861, he resigned from his position at a Cincinnati post office and enlisted into the Union Army where he was given the rank of lieutenant in Company K, 10th Ohio Infantry.

[2][3][4] On August 10, 1867, a provisional municipal government was organized in Cheyenne, Dakota Territory, with H. M. Hook as mayor.

Murrin was given the Democratic nomination for the mayoralty and defeated Republican nominee W. W. Corlett with 593 to 345 votes.

[9] On December 15, 1877, territorial Governor John Milton Thayer appointed Murrin, Simon Durlacher, and Thomas Lanktree as a penitentiary commission to oversee prisoners in Laramie County, Wyoming.