The opening of the Burlington Bay Skyway in 1958 bypassed the routing of Highway 20; it was truncated at the QEW in Stoney Creek in 1964 as a result.

[5] The remaining portion of the highway is mostly rural in nature, although numerous motels line the short stretch of roadway, reminiscent of a bygone era.

Moving eastward, a majority of motels line the south side of the highway, as do several residences and a strip club.

Beginning at an interchange with the QEW at Centennial Parkway, the highway travelled south, providing access to communities within Stoney Creek.

[8] The route exited Hamilton–Wentworth at Westbrook Road, entering the Region of Niagara and the municipality of West Lincoln after a brief swerve southward.

Southeast of the town, it curved south near St. Anns to Bismarck, where traffic had to turn to remain on the highway, which switched from a southward to eastward direction.

It proceeded south along John Street, concurrently with Highway 6, to the foot of the Niagara Escarpment, where the two routes split.

At the top, Highway 20 proceeded east along Concession Street, then south along Upper Gage Avenue to Rymal Road.

From there, the route turned east and followed Rymal Road to Elfrida and onwards to its eastern terminus at the Honeymoon Bridge Niagara Falls.

This prompted the DHO to construct a skyway over the canal, which opened on October 30, 1958, and provided four lanes of uninterrupted travel.

[citation needed] As part of a series of budget cuts initiated by premier Mike Harris under his Common Sense Revolution platform in 1995, numerous highways deemed to no longer be of significance to the provincial network were decommissioned and responsibility for the routes transferred to a lower level of government, a process referred to as downloading.